Abstract

Preparation and Evaluation of Film Coated Ketoprofen Tablets

This study deals with formulation and enhanced dissolution characteristics of ketoprofen through preparation of its nanoparticles solid dispersion systems(NSDS) with different synthetic polymers aiming to increase its dissolution rate of this poorly water soluble drug. The carriers used to prepare solid dispersion of nanoparticles include Bcyclodextins , PEG3350 , PEG6000 , PVP K30 and PVPK90 . Results of studies revealed that ketoprofen depicted its least solubility at lower pH values and had good solubility in basic medium. The official dissolution medium of ketoprofen is pH 7.5 pH .Lyophilization of ketoprofen with different polymers improved its flowability to great extent which in-turn improved its solubility and dissolution in comparision with plain drug. Ketoprofen nanoparticles prepared with a blend of B-cyclodextins , PEG 6000 and PVP K30 exhibited the highest dissolution rate(102.2%) when compared with other nanoparticles prepared with other polymers . It was found that the dissolution and solubility data were in accordance with XRPD , DSC and FTIR. The kinetic analysis revealed that dissolution data of the most formulae were according to Higuchi model, zero and first order kinetics.


Author(s): Mohammed M. M. Nafady, Khaled M. Attala and Mohamed A. Sayed

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