Abstract

Preparation and evaluation of Aceclofenac floating oral delivery system

The present work was carried out to prepare and evaluate floating drug delivery system of aceclofenac using various grades of low-density polymers such as HPMC and ethyl cellulose alone or in combination in various proportions. The microspheres were prepared by emulsionsolvent diffusion method. The drug retained in the floating microspheres decreased with increase in HPMC content. The floating microspheres were found to be spherical by SEM. FT-IR study confirmed the drug-polymer compatibility. All floating microspheres formulations showed good flow properties. Floating ability was tested in 0.1 N HCl containing 0.02% Tween 20. The formulation BP6 exhibited balance between floating ability and release. The prepared formulation will minimize the irritant effect of aceclofenac on the stomach by avoiding direct contact with the mucosa and providing a mean of low dosage for prolonged period


Author(s): Sengodan Tamizharasi, T. Sivakumar and Jagdish Chandra Rathi

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