Preparation and evaluation of Aceclofenac floating oral delivery system

The present work was carried out to prepare and evaluate floating drug delivery system of aceclofenac using various grades of low-density polymers such as HPMC and ethyl cellulose alone or in combination in various proportions. The microspheres were prepared by emulsionsolvent diffusion method. The drug retained in the floating microspheres decreased with increase in HPMC content. The floating microspheres were found to be spherical by SEM. FT-IR study confirmed the drug-polymer compatibility. All floating microspheres formulations showed good flow properties. Floating ability was tested in 0.1 N HCl containing 0.02% Tween 20. The formulation BP6 exhibited balance between floating ability and release. The prepared formulation will minimize the irritant effect of aceclofenac on the stomach by avoiding direct contact with the mucosa and providing a mean of low dosage for prolonged period

Author(s): Sengodan Tamizharasi, T. Sivakumar and Jagdish Chandra Rathi

Abstract | PDF

Share This Article
30+ Million Readerbase
Google Scholar citation report
Citations : 374

Der Pharmacia Sinica received 374 citations as per Google Scholar report

Abstracted/Indexed in
  • Google Scholar
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • Proquest Summons
  • International Committee of Medical Journal Editors (ICMJE)
  • Serials Union Catalogue (SUNCAT)
  • Geneva Foundation for Medical Education and Research
  • Secret Search Engine Labs

View More »

Flyer image