Preparation and characterization of solid dispersion of modafinil for enhancement of dissolution rate

Solid dispersions of Modafinil were prepared using polyethyleneglycols, in various proportions by melting, solvent evaporation and simple mixing methods. Based on the solubility and melting point study, PEG 8000 was selected and solid dispersion batch containing drug: PEG 8000 in the ratio of 1:4 was prepared by melting method and then formulated as tablet followed by evaluation of dissolution and six month stability studies. When the results of selected tablet batch were compared with that of tablet containing physical mixture of drug:PEG 8000 in the ratio of 1:4 and conventional tablet containing plain Modafinil, it has shown significant improvement of dissolution profile of Modafinil Present study conclusively demonstrated that PEG 8000 enhanced water solubility of Modafinil by amorphization, which was confirmed by XRPD, FTIR, SEM and DSC. The melting method was found better than solvent evaporation method for enhancement of dissolution profile.

Author(s): Krishna B. Patel

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