Precision Medicine in the Treatment of Alzheimer's disease: Opportunities and Challenges

Precision medicine is an innovative approach that takes into account the individual variability in people’s genes, environmental exposures and lifestyle. Precision medicine contradicts the traditional “one-size-fitsall” approach in which treatments and prevention strategies of a particular disease reflect the average person without taking into account the individual variability. Omic sciences offer the opportunity to generate these more precise individual date that can guide the prevention, risk assessment, and treatment strategies of diseases. Omic-based technologies can be used to identify novel biomarkers that could be targets for therapeutic intervention. In this literature review, the opportunities and challenges of implementing precision medicine in the treatment of Alzheimer disease will be addressed. A comprehensive literature search was conducted in the period from October 2017 to January to collect and research articles that contain information about the opportunities and challenges of implementing precision medicine in the treatment of neurological diseases, more specifically Alzheimer’s. PubMed is the database that was used to collect such information. There were 76 article hits, of which 18 were included in this review. Inclusion criteria were: full-text, English written, and published in the last 10 years. Articles that are not focused on Alzheimer disease, or precision medicine were excluded from this review

Author(s): Mohammed Kilani

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