Mangrove plants are widely used folk remedies and ethno botanical literatures have described the usage of plant extracts to treat human diseases since time immemorial. Avicennia marina (Forssk.) Vierh (A. marina) commonly known as grey mangrove has been used as traditional medicine for decades with multifunctional biological activity. We have identified 60 different compounds in the methanolic extract of A. marina by GC/MS and LC/MS analysis. The methanolic extract of A. marina shows higher content of pentanoic acid, decanoic acid, diethylhydroxylamine, pyrrolidine, 4-chlorophenyl, octadecylisocyanate, thiazolidinones and arabinopyranoside (flavonoid) which could be used as an alternative herbal medicine with wide range of biological properties such as anti -oxidant,- tumor,- microbial, -inflammatory, -allergic, -ageing and -artherosclerotic with minimum risk of adverse effects and with maximum potency that ensure better quality of life during treatment.