Epsom salt is chemical salt with mixture of magnesium and sulfate ions. Epsom salt and table salt are different in their chemical structure. Epsom salt plays various pharmaceutical effects in medical field, where it affects various body organs. It plays an important role in release of pain due to its effect on nerve and its characters' as antiinflammatory and treatment of muscle cramps. Also, Epsom salt has beauty influence on body care due to its effect on skin and feet. Not only Epsom salt has grade effect on health of human being but also it has effect on plants growth through its effect on soil, and insect. In this short communication we summarize the biological effects of Epsom salt.