Tuberculosis (TB), one of the deadliest diseases is creating an impediment in human health world widely. Mycobacterium tuberculosis causes pulmonary TB, which later on shifts its impact on other body organs rather than only lungs. So here bacilli generate the extra-pulmonary form of TB. Genito-urinary form of EPTB is world’s second most risky form of TB which brings ill effects on reproductive health of population. GUTB is much more destructive which affects males and females both but in males, susceptibility towards disease is more. Now-a-days infertility is the major concern in both males and females which arises due to the infection of bacilli in genital organs. Some frequent symptoms like dysuria, pyuria, abdominal pain, hematuria may be observed and fever, weight loss, anorexia are less common. GUTB can be diagnosed on the basis of various culture studies and also through the radiological imaging by ultra sound, pelvic MRI etc. PCR is also best method for the diagnosis of the bacilli of MTB in urine and the ideal result can be obtained within 24-48 hours. Surgery is also preferred if kidney or epididymis is infected with the bacilli.