Neuroprotective activity of methanol extract of Salvia officinalis flowers in dementia related to Alzheimer disease

Salvia officinalis is a Ayurvedic traditional medicinal plant in India and is considered useful in various ailments. Preliminary neuropsychopharmacological evaluation revealed cognition enhancing ability of the flower extract of the plant. Therefore, the present study aims at evaluating the potential effectiveness of the methanol extract of the flowers of this plant in dementia related to Alzheimer’s disease (AD). Dementia was induced experimentally in animals by ingesting excess Copper and Aluminium in drinking water and confirmed by Radial 8 arm maze test. Differentl biochemical parameters including superoxide dismutase (SOD), glutathione-oxidized (GSSG), reduced glutathione (GSH), nitrite estimation, myeloperoxidase (MPO) activity and acetylcholinesterase (AChE) activity were also estimated. Lipid profile was also evaluated along with the histopathological observations. Results demonstrated a neuroprotective profile of the methanol extract of the flowers of Salvia officinalis as well as revealed a reversal of the dementia related to AD.

Author(s): M. Shamnas

Abstract | PDF

Share This Article
30+ Million Readerbase
Google Scholar citation report
Citations : 374

Der Pharmacia Sinica received 374 citations as per Google Scholar report

Abstracted/Indexed in
  • Google Scholar
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • Proquest Summons
  • International Committee of Medical Journal Editors (ICMJE)
  • Serials Union Catalogue (SUNCAT)
  • Geneva Foundation for Medical Education and Research
  • Secret Search Engine Labs

View More »

Flyer image