Multimodal Role of Exosomes in COVID-19 Transmission, Diagnosis, and Therapy

Exosomes are membrane vesicles of endocytic origin released by all cell types under physiological and pathological conditions. Exosomes are important mediators
of the cell to cell communications and transport biomolecules, including lipids, proteins, DNAs, messenger RNAs, and microRNAs, and perform the intercellular transfer of
components, locally and systemically. Moreover, exosomes generated by virus-infected cells can partake into key viral proteins and fragments of viral RNA, thus effectively
carrying the viral load to other healthy cells, facilitating viral transmission. In this review, we focus on the role of exosomes in the transfer of SARS-CoV-2 infection and how these virus-loaded exosomes can be used to develop effective therapeutic options.

Author(s): Abhishek Dutta

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