Mucoadhesive microcapsules of amoxicillin trihydrate for effective treatment of H. pylori

The aim of present research work was to develop amoxicillin trihydratemucoadhesive microcapsules to prolong residence time of dosage form in stomach and to achieve controlled drug release for more effective H. pylori eradication. Microcapsules containing sodium alginate and mucoadhesive polymer (carbopol 934 P, Hydroxy Propyl Methyl Cellulose (HPMC), Sodium Carboxy Methyl Cellulose (SCMC), and Methyl Cellulose (MC))were prepared by orifice ionic gelation method and evaluated for morphology, particle size analysis, percentage yield, drug content, drug entrapment efficiency, swelling ratio, mucoadhesive properties and in vitro drug release. Prepared microcapsules were spherical, free flowing and exhibited good mucoadhesive property. Average particle size for microcapsules was in the range of 300 to 550 μm and encapsulation efficiency was in the range of 51–69%. Formulations containing alginate-carbopol 934P as showed more mucoadhesion, swelling and drug entrapment efficiency than alginate-HPMC, alginate-SCMC and alginate-MC. As per pictures of scanning electron microscopy, optimized batch F9 (containing one part of carbopol and nine parts of alginate) proved that microcapsules were spherical having size range of 500-550μm and uniformly covered with the coat polymer. The optimised batch showed zero order drug release up to 10 - 12 h which suggested that the optimised mucoadhesive microcapsules are promising for controlled drug delivery of amoxicillin trihydrate for effective treatment.

Author(s): Sonia Pandey

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