Molecular interaction study of substituted azomethine drugs refractometrically

The densities and refractive index of substituted azomethine drugs of different concentration in 70% (DMF+water) binary mixture has been studied. The experimental data shows that the molar refraction and polarizability constant of substituted azomethine drugs decreases with decrease in concentration of ligand in 70%(DMF+ water) solvent and increases with increase in percent of organic solvent, over a constant ligand concentration. The data helps to predict the solute-solute, solute-solvent and solvent-solvent interaction in the system.

Author(s): A. V. Kawalkar and M. P. Wadekar

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