Micelle encapsulation of ferromagnetic nanoparticles of iron carbide@iron oxide in chitosan

In this work, the synthesis and characterization of core@shell nanoparticles of Fe₃C/γ-Fe₂O₃ encapsulated into micelles of sodium dodecylsulfate and oleic acid stabilized with chitosan was developed. The nanoparticles were sonosynthesized at low intensities using iron pentacarbonyl (Fe(CO)₅) and oleic acid as iron source and hydrophobic stabilizer, respectively; obtaining a hydrodynamic diameter of 19.71 nm and PDI of 0.134. These nanoparticles were used as the organic phase during the production of a nanoemulsion with sodium dodecylsulfate and water. The final step, involved the stabilization of the nanoemulsion using low molecular weight chitosan solution at 2% in acetic acid by ultrasonication. The nanosystem showed a hydrodynamic diameter of 185.3 nm, a PDI of 0.150 with a superficial charge ζ of 36.7 mV. Due to these physical and chemical properties, it is believed that this type of nanoparticles can be use as theranostic agent.

Author(s): Paul Zavala-Rivera

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