Linezolid study on isolates of Staphylococcus aureus and Escherichia colithrough disc diffusion Method

Antibiotic was seeing wonder drugs when they appeared because antibiotic can treat every infection. As soon, it was observed that the treated bacteria can build resistance in contrast to them and the resistance can be intrinsic or acquired. The antibiotics are chemical compounds, which minimize the production of microorganism and ultimately kill microorganism. Natural fermentation or chemical synthesis may help in the production of these drugs. The antibiotics are the drugs, which are obtained from the compounds by different microbial flora. It is also noted that not every antibacterial compounds are antibiotics and obtained completely by chemical synthesize. Though moldy materials helped in healing the wounds and infections, but it was observed in late 19th century that this was due to the microbes. Flemingâ??s, Chainâ??s and Floreyâ??s clinical observations, development studies made a new innovation in antibiotics in the twenty century. The new addition in the antimicrobial world is the oxazolidinone group of antibiotics which can play various significant roles in order to combat the infections occurred by Gram positive bacteria. The oxazolidinone provides greater result in contrast to Gram positive microorganisms and produces high resistance against microbial in clinical situations. Oxazolidinone is very useful and also shows a moderate microbial effectiveness in contrast to Gram negative bacteria. Oxazolidinone substances are structurally available with 2- oxazolidinone. Oxazolidinone antibacterial compounds were seen problematic because they produced toxic effects in clinical studies. After few years oxazolidinone class was studied more for enhancing efficacy and safety, with the introduction of two vital and useful compounds like Eperezolid and Linezolid. Bioactive and toxic examination of both of a Linezolid and Eperezolid were almost same, so clinical testing was performed.
Author(s): Syed Akif Uddin

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