Isolation, characterization and antibacterial activity screening of a new β-carboline alkaloid from Datura metel Linn.

Datura metel Linn. (Solanaceae) is a well-known medicinal plant commonly used in phytomedicine to cure diseases and heal injuries. Chemical investigation of the bioactive constituents from the leaves of D. metel afforded a new β-carboline alkaloid (1, 7 dihydroxy-1- methyl 6, 8 dimethoxy β-carboline). The structure was elucidated using NMR spectroscopy in combination with IR and MS spectral data. Antibacterial studies showed that the isolated compound successfully inhibited Pseudomonas aeruginosa, Klebsiella Pneumonia, Staphylococcus aureus, Proteus mirabilis, Escherichia coli, Bacillus subtilis and Salmonella typhi. This result supported the use of this plant in wound treatment

Author(s): Donatus Ebere Okwu , Ephraim Chintua Igara Department

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