Insulin resistance and obesity among infertile women with different polycystic ovary syndrome phenotypes

Insulin resistance and obesity among infertile women with different polycystic ovary syndrome phenotypes

Moamar Al-Jefout

Mutah Medical Faculty, Mutah University, Jordan



Insulin obstruction is when cells in your muscles, fat, and liver don't react well to insulin and can't utilize glucose from your blood for vitality. To compensate for it, your pancreas makes more insulin. After some time, your glucose levels go up.

The insulin obstruction condition incorporates a gathering of issues like heftiness, hypertension, elevated cholesterol, and type 2 diabetes. It could influence upwards of 1 out of 3 Americans. You may likewise hear it called a metabolic disorder.

Indications of Insulin Resistance

You can't tell that you have insulin obstruction by how you feel. You'll have to get a blood test that checks your glucose levels.

In like manner, you won't know whether you have a large portion of different conditions that are a piece of insulin obstruction disorder (hypertension, low "great" cholesterol levels, and high triglycerides) without seeing your PCP.

  • A few indications of insulin obstruction include:
  • A waistline more than 40 creeps in men and 35 crawls in ladies
  • Circulatory strain readings of 130/80 or higher
  • A fasting glucose level of more than 100 mg/dL
  • A fasting triglyceride level of more than 150 mg/dL
  • A HDL cholesterol level over under 40 mg/dL in men and 50 mg/dL in ladies
  • Skin labels
  • Patches of dull, smooth skin called acanthosis nigricans
  • Hazard Factors and Causes of Insulin Resistance
  • Things that can make this condition more probable include:
  • Heftiness, particularly midsection fat
  • Idle way of life
  • Diet high in sugars
  • Gestational diabetes
  • Wellbeing conditions like nonalcoholic greasy liver malady and polycystic ovary disorder
  • A family ancestry of diabetes
  • Smoking
  • Ethnicity - it's almost certain if your heritage is African, Latino, or Native American
  • Age - it's almost certain after 45
  • Hormonal scatters like Cushing's disorder and acromegaly
  • Meds like steroids, antipsychotics, and HIV drugs
  • Rest issues like rest apnea

Determination and Tests for Insulin Resistance

Oral glucose resilience test. To start with, you'll take the fasting glucose test. At that point, you'll drink a sweet arrangement. Two hours from that point onward, you'll take another blood test.

Hemoglobin A1c test . This blood test shows your normal glucose level for as long as 2 to 3 months. Specialists use it to analyze prediabetes or diabetes. On the off chance that you have diabetes, it helps show whether it's leveled out. You may need to step through the exam again to affirm the outcomes.Polycystic ovary syndrome (PCOS) is a common problem among Arab women and is the main cause of infertility due to anovulation. This study investigates insulin resistance (IR) and obesity in different PCOS phenotypes among infertile women (n = 213), of whom 159 had PCOS and 54 women without PCOS, recruited as a control group. Biometric, hormonal and clinical parameters were studied. IR was observed in 133 (83.6%) women with PCOS and in 25 (46.3%) women without PCOS (p <0.001). IR was significantly associated with PCOS only among women with central obesity (χ2 = 35.0, p <0.001) and not for the normal category (χ2 = 4.04, p <0.058). The LH/FSH ratio was not significantly different among the PCOS group (n = 37, 23.3%) compared to the control group (n = 9, 16.7%) (p = 0.308). Among women with PCOS, the most common phenotype was type I (50.3%), with type III (29.6%), type II (14.5%) and type IV (5.7%). Type I had the highest values of fasting insulin (median = 12.98 mU/mL) and HOMA IR values (significant difference among the four phenotypes, p= 0.009 and 0.006, respectively) and is associated with severity of the disease. There was no difference in glucose levels.


Author(s): Moamar Al-Jefout Mutah Medical Faculty, Mutah University, Jordan  

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