Abstract

Incidence of Acute Neurologic Complications after Heart Surgery in Children with Congenital Heart Disease: A Systematic Review and Meta Analysis

The aim of this systematic review and meta-analysis was to evaluate the Incidence of Acute Neurologic Complications after Heart Surgery in Children with Congenital Heart Disease.The searches were conducted by two independent researchers (MS, ZM) to find the relevant studies published from 1/1/2009 to the end of 30/12/2018. We searched for published literature in the English language in MEDLINE via PubMed, EMBASETM via Ovid, The Cochrane Library, and Trip database. For literature published in other languages, we searched national databases, KoreaMed and LILACS, and we searched OpenGrey and the World Health Organization Clinical Trials Registry for unpublished literature and ongoing studies.The keywords used in the search strategy were: Neurologic Manifestations, Thoracic Surgery, complications, children,Heart Defects, Congenital - heart disease and children, which were combined using the AND, OR, and NOT operators.Finally, a meta-analysis was conducted in STATA14 statistical software.A total of 5773 patients with congenital heart disease who had undergone the heart surgery were studied. The age of the participants varied between 15 days to 18 years.Based on the random effect model the total prevalence of neurologic complications in 5773 patients with congenital heart disease who had undergone the heart surgery was 3% (95% confidence interval [CI]:2.6,3.4, I2=94%) with seizure being the most prevalent neurologic complication with a prevalence of 1.4% (95% confidence interval [CI]:1.1%,1.8%, I2=73.5%).It was showed that overall rate of neurological complication was higher in studies with higher female to male ratio.The frequency of neurologic complications after congenital open-heart surgery was 77.1% (95%CI 75%,79.1%) of all kind of cardiac surgeries moreover, the frequency of neurologic complications after congenital close heart surgery was 19.2% (95%,16.8%,21.5%) of all kind of cardiac surgeries.


Author(s): Fateme Parooie*, Zohre Mahmoodi

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