Reach Us +44 118 315 0749

Abstract

In vitro Study of Antioxidant and Antimalarial Activities of New Chromeno- Pyrano-Chromene Derivative

A new molecule of 2-[3, 4 di hydroxy phenyl] 3, 5, 14-trihydroxy 13- oxo 2H-chromeno [3141:5, 6] pyrano [2, 3-h] 4H-chromene 4-one was synthesized and screened. This new compound was synthesized by incorporating 4-chloro-3-formyl coumarin group with quercetin compound. In the present study the antioxidant and antimalarial activities of new 2-[3, 4 di hydroxy phenyl] 3, 5, 14-trihydroxy 13- oxo 2H-chromeno [3141:5, 6] pyrano [2, 3-h] 4H-chromene 4-one molecule was studied. The Antioxidant activity was performed by 1, 1-diphenyl-2-picryl hydrazyl free radical scavenging activity, phosphomolybdenum method, reducing power method and scavenging of nitric oxide methods and the calculated IC50 values for new molecule and reference standard gallic acid were 1.77μg/ml, 0.13μg/ml respectively for DPPH method and 1.93μg/ml, 0.28μg/ml respectively for nitric oxide method. The antimalarial activity was performed by SYBR green I assay and by inhibition of β-hematin formation. These findings reveal that the new molecule 2-[3, 4 di hydroxy phenyl] 3, 5, 14-trihydroxy 13-oxo 2H-chromeno [3141:5, 6] pyrano [2, 3-h] 4H-chromene 4-one has good antimalarial and antioxidant activities and could be an alternate candidate for the development of new biologically active compounds.


Author(s): K. Ravi Shankar, N. Sita Ratna Kumari and G.V.N. Kiranmayi

Abstract | PDF

Share This Article
17+ Million Readerbase
Recommended Conferences
Google Scholar citation report
Citations : 2055

American Journal of Phytomedicine and Clinical Therapeutics received 2055 citations as per Google Scholar report

Abstracted/Indexed in
  • Google Scholar
  • Sherpa Romeo
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • Open Academic Journals Index (OAJI)
  • Directory of Research Journal Indexing (DRJI)
  • Publons
  • Scientific Journal Impact Factor
  • International Committee of Medical Journal Editors (ICMJE)
  • Secret Search Engine Labs
  • Euro Pub

View More »

Flyer image