The inflammatory process is triggered for tissue repair following an attack of pathogens, chemicals or cell damages. Although beneficial, chronic inflammation may be the cause of certain diseases. Non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids have many side effects. Plants with anti-inflammatory properties may lead to the discovery of new anti-inflammatory agents with fewer side effects and cost. In this study, in vitro antiinflammatory effect of glycosidic and aglyconic crude extracts of Cassia sieberiana and Khaya grandifoliola was evaluated using membrane stabilization of erythrocytes and inhibition of proteins’s denaturation tests. For this purpose, Acetylsalicylic acid has been used as a reference like NSAID. The results obtained showed an antiinflammatory effect more pronounced of aglycones that respective glycosides. This suggests that the deglycosilation can enhance the anti-inflammatory activity.