In vitro antioxidant and renoprotective potential of methanolic extract of Verbascum thapsus leaf in rats

Kidney disease are the most leading causes of death in world. In this study the effect of oral administration of methanolic extract of Verbascum thapsus leaf at the dose of 250 & 500 mg/kg was studied on gentamicin induced nephrotoxicity in wistar rats using Silymarin as a standerd drug at a dose of 50 mg/kg, and it significantly reduced nephrotoxicity by reducing the elevated creatinine, urea and blood urea nitrogen level. In addition to that, significant decrease in lipid peroxidation (MDA level) and increase in catalase, superoxide dismutase, reduced glutathione were observed in kidney tissue homogenate. Thus show nephroprotective effect threw antioxidant activity and anti oxidant activity is conformed by in vitro evaluation threw DPPH radical scavenging, Nitric oxide scavenging, Reducing power assay.
Author(s): Himanshu Pal, Tirath Kumar and Himani Karki

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