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Hypolipidemic effects and Antioxidant Activity of Tocotrienols on Cigarette Smoke Exposed Rats

Cigarette smoking is one of the major causes of mortality involving respiratory and cardiovascular illness in developing countries. Cigarette smoking is known to contain abundant of free radicals, which is able to cause tissue oxidative damage at various levels and to the alterations which induce the arteriosclerotic process. The body has the ability to produce hepatic antioxidants such as Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (Gpx) and Glutathione reductase (Gred). When there are excessive free radicals generated due to smoking, the available tissue antioxidants may become depleted, leading to oxidative stress. In this study we investigate the efficacy of antioxidant and hypolipidemic agent Tocotrienols by analyzing all the parameters in plasma lipoprotein lipids, TL, TC, TG, VLDL-C, LDL-C, HDL-C, as well as hepatic antioxidant enzymes (SOD, CAT, Gpx and Gred), as investigated in smoke exposed control rats. All the plasma lipids parameters as well as hepatic antioxidant enzymes were significantly increased/decreased in smoke exposed control rats. After 4 weeks administration of Tocotrienols, significantly restore the above altered parameters. In conclusion, Tocotrienols may be useful in the prevention and treatment of tobacco-induced dyslipidemia/hyperlipidemia and atherosclerosis

Author(s): Abhay Singh Chandel1, Amir Khan2,*, Fouzia Ishaq3, Samir Chhetri1, Seema Rawat2 and Deepti Malhotra4

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