Human Genetics 2018: How Next Generation Sequencing is going to transform how we treat cancer patients_David I Smith_Mayo Clinic, USA

Human papillomavirus (HPV) is concerned within the development of variety of anogenital cancers and is progressively concerned within the development of cavum epithelial cell malignant neoplastic disease (OPSCC), a cancer of the bottom of the tongue and also the thyroid. a lot of what's presently better-known concerning HPV role in cancer development comes from studies of cervical cancer. ladies whose system doesn't clear the HPV virus square measure at AN enlarged risk of developing cervical cancer. Infection of the cervical epithelial tissue with HPV causes cellular immortalization however further alterations square measure needed for invasive cancer to develop. One such alteration within the integration of the HPV virus into the human order that is discovered in most, however not all, cervical cancers. we've been learning HPVs role within the development of OPSCC victimisation many whole order sequencing ways. the primary is mate try next-generation sequencing on the Illumina sequencing platform. The second is whole order sequencing (WGS) on the BGI sequencing platform. These studies have discovered that HPVs role within the development of OPSCC is completely different than in cervical cancer as HPV is simply integrated into concerning half-hour of HPV-positive OPSCCs. what is more, these studies have incontestable that HPV plays completely different roles within the development of various OPSCCs. WGS not solely will verify wherever HPV has integrated into the human order however additionally the structure of the body region once the mixing event. WGS may also characterize several different genomic alterations that occur in these cancer genomes. i'll describe our work characterizing however we've used order sequencing to review HPVs role within the development of OPSCC. many of us with HPV do not develop any symptoms however will still infect others through sexual contact. Symptoms could embrace warts on the sex organ or encompassing skin. there is not any cure for the virus and warts could get away on their own. Treatment focuses on removing the warts. A immunogen that forestalls the HPV strains presumably to cause reproductive organ warts and cervical cancer is suggested for boys and women. HPV infection may be a virus infection that ordinarily causes skin or mucosa growths (warts). There square measure quite one hundred kinds of human papillomavirus (HPV). Some varieties of HPV infection cause warts, and a few will cause differing kinds of cancer. Most HPV infections do not cause cancer. Common symptoms of some varieties of HPV square measure warts, particularly reproductive organ warts. reproductive organ warts could seem as atiny low bump, cluster of bumps, or stem-like protrusions. They ordinarily have an effect on the female genitalia in ladies, or probably the cervix, and also the member or pouch in men. they will additionally seem round the opening and within the groin. there is not any cure for the virus and warts could get away on their own. Treatment focuses on removing the warts. A immunogen that forestalls the HPV strains presumably to cause reproductive organ warts and cervical cancer is suggested for boys and women. Most reproductive organ HPV infections are not harmful in the least and get away on their own. however, some types of HPV will cause reproductive organ warts or bound varieties of cancer. 2 varieties of HPV (types six and 11) cause most cases of reproductive organ warts.
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Author(s): David I Smith

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