Not just for genome stability, but also for cell viability, accurate and full genome replication is required. Cells, on the other hand, are constantly threatened by spontaneous DNA alterations and DNA lesions from both endogenous and exogenous sources, which provide a persistent threat to the replication process. Replication stress is defined as any hurdle that delays replication forks or disrupts replication dynamics, and we've learned a lot about how cells respond to and resolve such obstacles in the last decade. Furthermore, new research has discovered linkages between replication stress response deficiencies and genomic instability or illnesses like cancer. Histone dynamics are important in controlling fork progression and replication stress responses because replication stress occurs in the presence of chromatin.