Histomorphometric Effects of Crude Methanolic Extract of Garcinia kola Seeds on the Hippocampus of Adult Wistar Rats

This study was designed to investigate the histomorphometric effect of garcinia kola on nickel chloride induced neurotoxicity in adult Wister rats. Thirty (30) rats were used for this study. The rats were divided into five (5) groups of six (6) rats each. Group A received 1 ml/kg body weight distilled water, Group B received 20 mg/kg body weight of nickel chloride, Group C received 20 mg/kg body weight of nickel chloride and 100 mg/kg of crude extract of garcinia kola seeds, Group D received 20 mg/kg body weight of nickel chloride and 200 mg/kg of crude extract of garcinia kola seeds and Group E received 20 mg/kg of crude extract of garcinia kola seeds concomitantly for 21 days. At the end of the experimental period, brain tissues were harvested and taken for histopathological examination. Results obtained showed that the exposure of rats to nickel chloride lead to the degeneration of neuronal cells and significant loss of body weight. However, the administration of the crude extract of garcinia kola with nickel chloride limited the damaging effect of nickel chloride. The present findings showed the ameloriative potential of garcinia kola on nickel chloride induced neurotoxicity in adult wistar rat.

Author(s): Akinola BK

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