Cancer is one of the leading and most fatal diseases in the present decade, every year millions of people die because of various types of cancers. Many aspects relate to the cause of disease besides heredity, food habits, smoking, nutritional behaviours, radiation etc. The successful cancer therapy till now has been under research, only chemotherapy and radiation treatments are at times successful and much times toxic and lethal. Alternative and less toxic medication is very much in need towards the disease, the use of concepts of herbal medicine with knowledge of Ayurveda could present better drug leads towards the inhibitory treatment of Cancer. Nature shows plethora of medicinal plants with anticancer and antioxidant activities which may suppress the disease completely. The search for cancer drugs from natural sources started in late 1960s, lead to discoveries of vincristine, vinblastine, campthothecin and taxol. This review certainly focuses on the herbal medicine from natural products for the discovery of new drug leads towards the cancer treatment.