Brassica juncea is a cruciferous cormophyte medicinal plant. Despite its popular usage, no study has been published concerning its hepatoprotective activity till date. This study was designed to evaluate the effects of Brassica juncea leaf extracts on carbon tetra chloride (CCl4) induced Wistar albino rat model. The animals were divided into 7 groups (Normal, Positive control, Standard, Pet ether, Chloroform, Ethyl acetate and Ethanol). Liver marker enzymes were assayed in serum. Samples of livers were observed under microscope for the histopathological changes. Serum levels of alanine amino transferase (ALT), Aspartate amino transferase (AST), alkaline phospahtase (ALP) and bilirubin level were significantly increased in positively control group. Among different extracts groups, ethanolic extract and pet ether group indicates maximum inhibition of necrosis shows reduction of ALT, AST ALP and total bilirubin give highly significant results p<0.0001. Ethyl acetate did not show any significant result. In conclusion the pet ether and ethanolic leaf extract of Brassica juncea could be a better drug of choice as a hepatoprotective plant source for the liver patients.