Abstract

Hepatoprotective and anti allergic study of various extracts of Argyrea speciosa, sweet root extracts in experimental animals

The various sutras in ayurveda illustrates that a person undergoing rejuvenation therapy attains longevity, memory, intellect, freedom from diseases, youth, excellence of luster, true sense-organ and respect, brilliance and vak-siddhi. This rejuvenation therapy is known as Rasayana therapy. The materials used in the therapy are termed as Rasayana. These Rasayana may be inducers of enzymes and hormones, which the body needs for adaptations and survival during normal health, stress and during the diseases also. This concept of Rasayana is well known to ayurvedic physicians that the delicate cellular machinery of the body fluids from trauma (stress) resulting in wear and tear of different body structures and deterioration of the functional capacity such as liver. This procedure of revitalization and rejuvenation were adopted to increase the power of resistance to disease (increased immunity). The plant Argyrea speciosa, Sweet, is not explored scientifically for its medicinal values or for any of its use except few studies like antibacterial activity. There is a need for supplementation of exogenous antioxidants to protect the body from the onslaught of free radical induced damage, in such conditions. Hence our aim was to explore the hepatoproctective and antiallergic effect Argyrea speciosa, sweet root extracts in experimentally induced hepatotoxicity and allergy in animals. The roots were shade dried and powdered. The roots were defatted with petroleum ether (60-80º) and further extracted with distilled water (ASW), methanol (ASM) and under Soxhelet extraction and methanolic fraction of aqueous extract (ASMW) was prepared. The aqueous, methanolic and methanolic fraction of aqueous extract of Argyrea speciosa Sweet have exhibited significant protection against the deleterious effects like various diseases and conditions like liver damage and allergy. The results indicated potent hepatoprotective activity which may be attributed to the membrane and cellular stabilizing activity of extracts. The results also indicated potent anti allergic activity which may be attributed to prevention of sensitization or inhibiting the release of various allergic mediators.


Author(s): Pandurang M. Gaikwad, S. Vidyadhara and Vikram V. Nimbalkar

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