Ecofriendly or Green synthesis of metal nanoparticles has become an important branch of nanotechnology and there is an increasing commercial demand for nanoparticles due to their wide applications. In the present study, we report an eco-friendly and economical way for the synthesis of silver nanoparticles using leaf extract Azadirachta indica. The plant properly known as ‘neem’ belongs to the family Meliaceae. For the synthesis of silver nanoparticles (SNPs) using the leaf extract of Azadirachta indica as a reducing agent from 1 mM silver nitrate (AgNO3) has been investigated. The resulting SNPs are characterized using UV–Vis, TEM. Silver nanoparticles were synthesized within 24 hours of incubation period and synthesized SNPs showed an absorption peak at around 400 nm in the UV-visible spectrum. The morphological study of Silver nanoparticles using TEM suggests that the nanoparticles are spherical in shape with a diameter around 50-nm. This route is rapid, simple without any hazardous chemicals as reducing or stabilizing agents and economical to synthesized SNPs.