Gas powered controlled drug delivery system of Secnidazole for spatial and temporal control

One of the most vulnerable gastro intestinal tract infections affecting the human population worldwide are H pylori infections. It causes complicated gastric problems such as gastritis, gastro duodenal ulcers, gastric cancer and primary B-cell gastric lymphoma. In the present study, Secnidazole was used for preparing floating dosage forms that are designed to retain in the stomach for a long time and have developed as a drug delivery system for better eradication of Helicobacter Pylori in peptic ulcer diseases. Hydroxy Propyl Methyl Cellulose (HPMC) and carbopol in different concentrations were used as floating agents; sodium alginate was used as a gel forming agent and sodium bicarbonate and citric acid as effervescent agents for spatial and temporal control of Secnidazole. Eight formulations (F1-F8) were prepared and evaluated for various physical parameters, Hardness, friability, content uniformity, floating ability and release profiles as well as kinetics of release were assessed. Selected formulations were able to float with the lag time of 1-10 minutes and showed buoyancy for at least 8 hrs. Meanwhile, sustained profiles of drug release were also obtained.

Author(s): Ram S. Pentewar, NishatKazi, Moin Attar, B. K. Sugave, Rohit Bharti and Gajanan Pulgamwar

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