FTIR molecular investigation on the concomitant effect of glycine and alcohol induced liver injury

Glycine is known to have a protective role against alcohol induced liver damage. The aim of our study was to evaluate the effect of glycine and alcohol treated albino rats, were analyzed for their lipid content and structural changes using Fourier transform infrared (FTIR) spectral and Light microscopic techniques, respectively. In the administering ethanol (5 g/kg body weight) every day to Wister albino rats for 45 days significantly elevated the lipid levels of liver was found to be increased as compared with the control rats. Simultaneous glycine supplementation (0.6 g/kg body weight) during 45 days of the experiment to rats administered alcohol reduced the lipid levels of tissue. As FTIR measurements are concerned, a vibrational assignment has been for the observed sub-band in the analysis in the C-H stretching region (3000-2800 cm^-1) of samples has shown clear changes interpreted on the basis of the structural made in the same samples. Light microscopic examination of ethanol treated rat liver showed inflammatory cell infiltrates and fatty changes, which were reversed on treatment with glycine.

Author(s): R. Selvaraju and K. Subbashinidevi

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