Formulation, Physico-chemical characterization and Release kinetic study of antihypertensive Transdermal Patches

The objective of the present study was to develop the matrix type transdermal patches of Carvedilol Phosphate (CP) using polymeric combination of polyvinylpyrrolidone (PVP) and ethylcellulose (EC) by solvent casting method over a backing membrane of polyvinylalcohol. All the prepared formulations were subjected to physicochemical studies like drug content, thickness, weight variation, moisture content, moisture uptake, water vapor transmission, flatness and folding endurance. The drug-polymer compatibility was ascertained by Fourier Transform Infrared spectroscopy (FTIR). The surface morphology and drug distribution in the patch was studied by Scanning Electron Microscopy (SEM). The release profile of the drug was evaluated by in-vitro dissolution study in 6-stage USP dissolution apparatusII, and in-vitro permeability study was done in 6 stage diffusion cell apparatus (FDC-06, Orchid Scientifics, Nashik) through dialysis membrane-70(LA 393, Hi Media). The results of physicochemical studies indicate the suitability of patch formulation of CP with the polymeric combinations of PVP and EC. The in-vitro drug release and permeation studies indicate that the required rate of drug release can be adjusted by selecting proper ratio of PVP and EC. Highest correlation was observed with Higuchi plot rather than first order or zero order. The present study has demonstrated the potential of the fabricated matrix transdermal patches of CP for sustained delivery through transdermal route.

Author(s): Pintu K De, Jibitesh Paul, Sanjoy K Dey, Subas C Dinda, Soumen Rakshit

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