Formulation, evaluation and comparison of Ketorolac tromethamine transdermal gel containing natural and synthetic permeation enhancers

The present research has been undertaken with the aim to develop a transdermal gel formulation of Ketorolac tromethamine, which would avoid the gastrointestinal related toxicities associated with oral administration. The various gastrointestinal disorders associated with oral administration of KT (NSAID’s) can be limited by delivering the drug by transdermal route to the inflammation site. Transdermal gels are becoming more popular because of ease of application, patient compliance and comparatively more percutaneous absorption than other semisolid formulations. Therefore, KT gel formulations were made with carbopol 940 having different concentration of tulsi oil and DMSO as penetration enhancers. KT gels containing various concentrations of tulsi oil and DMSO (2.5 %, 5.5 %, 7.5 %, 10.5 % and 12.5%) were prepared. The fixed oil of tulsi (ocimum sanctum) is reported to possess significant anti inflammatory activity. Formulations were evaluated for drug content, pH, viscosity, spreadability and drug release. In vitro release studies were performed using Franz diffusion cell. Release kinetic analysis was done to find the kinetics of drug release.

Author(s): Ajay Aggarwal

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