Formulation development and evaluation of Tamsulosin Hydrochloride and Dutasteride in tablet dosage form

The purpose of the study was to develop tablet in tablet (compression – coated tablets) having different release pattern, which is indicated for the treatment of Benign Prostate Hyperplasia. The study was planned in three stages. In the first stage, five batches (T1,T2,T3,T4,T5) of matrix tablet of Tamsulosin hydrochloride were prepared by wet granulation method, enteric coated and evaluated. Among the five batches, batch T3 was taken up for further studies. In the second stage, three batches (T6,T7,T8) of Dutasteride granules were prepared and evaluated. All three batches showed good flow property and drug content and taken up for further studies. In the third stage, three batches (T9,T10,T11) of compression – coated tablets were prepared, film coated and evaluated. Among three batches, batch T11 showed desirable properties and drug release. Hence batch T11 was considered as an optimized batch. The stability studies was determined for the optimized batch. This design of dosage form will open a new era for repeat action tablets.

Author(s): V. Ravichandiran, K. Masilamani, K. Punitha, S. Sureshkumar, B. Senthilnathan

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