Formulation, characterization and in-vitro evaluation of Cefixime floating matrix tablets

The present study was aimed to develop and evaluate the floating matrix tablets of Cefixime. The bioavailability of Cefixime is around 40-50 %. The gas powered tablets of Cefixime were prepared by direct compression method. Drug compatibility with excipients was checked by FTIR studies and these results were revealed that, no interaction between drug with the excipients used. The results of In-vitro buoyancy time and lag time study revealed that as the concentration of sodium bicarbonate increases, there is an increase in total buoyancy time and decrease in lag time. The formulation F8 shows the lag time of <1 min and buoyancy time 720 min. The release of Cefixime from all the formulations was in the range of 23.35±18- 89.00±99 % at the end of 16 hrs 75.95±13% and at the end of 24 hrs 89.28±43. From this study, it can be concluded that, the formulation retained for longer periods of time in the stomach.

Author(s): Phalguna Yadagiri

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