Abstract

Formulation and in vitro Evaluation Glimepiride and Parecoxib Mucoadhesive Tablets for diabetics associated with pain and inflammation

The main purpose of present study was to develop mucoadhesive tablets of Glimepiride and Parecoxib drugs were prepared to achieve controlled plasma level of the drug especially in diabetes mellitus patients with pain therapy. The mucoadhesive tablets were prepared by direct compression technique. The drug- excipient compatibility studies were performed by Fourier Transform Infrared spectroscopy (FTIR). Physicochemical characteristics and in vitro drug dissolution tests were performed. The in vitro drug release pattern and the dissolution data was treated with mathematical modeling Accelerated stability studies were also carried out to the optimized formulation (F-5). The FTIR studies revealed that drugs were compatible with the polymer used. The optimized formulations were found to have good physicochemical and in vitro release properties. The in vitro dissolution data was perfectly fitting to zero order and the release of drug from the formulation followed Higuchi’s release. The accelerated stability studies revealed that the tablets retain their characteristics even after stressed storage conditions. From this study it was concluded that Glimepiride and Parecoxib combination mucoadhesive Tablets is a good combination for diabetics associated with pain and inflammation.


Author(s): Narasimha Reddy D, Srinath MS, Hindustan Abdul Ahad, Sravanthi M and Kavitha K

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