ISSN : 0976 - 8688

Der Pharmacia Sinica

Abstract

Formulation and evaluation of fast dissolving sublingual tablets of amlodipine besylate

The aim of this study was to prepare fast disintegrating sublingual tablets of amlodipine besylate by using different disintegrant for the potential emergency treatment of angina and hypertension. The sublingual tablets of amlodipine besylate were prepared by direct compression using Tulsion 671 and crospovidone as a superdisintegrants. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, Wetting time, water absorption ratio and in vitro disintegration time. All prepared tablets shows the disintegration time less than 1 minute which was within Pharmacopoeial limit. All the formulations were evaluated for hardness, friability, thickness and weight variation. The results revealed that the tablets had acceptable hardness 3.15 – 3.59 kg/cm2 which further resulted into acceptable disintegration time 11-59 sec. It was found that the prepared formulations were also complying with the Pharmacopoeial standards for weight variation. Optimum formulation of Tulsion 671 and Crosspovidone in combination F-7 showed disintegration time of 11 seconds and 95.89 % of drug release.


Author(s): Kundan P. Chaudhari

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