Abstract

Formulation and evaluation of dry syrup containing bitter drug

Dosage forms are designed both for improving the physical and mechanical properties of materials, oral suspensions which requires mixing prior to administration is more acceptable and stable. They preferred when drug stability is a major concern. In present study solid dispersion technique was used for taste masking and dissolution enhancement. It has been defined as dispersion of one or more active ingredients in an inert carrier with solvent evaporation method used. In present study taste masking is most important phenomenon under study, as drug is bitter which is important issue for health care providers especially with paediatrics and geriatric patient. Taste masking generally achieved with solid dispersion technique. In which the taste of the final formulation were evaluated from human volunteers and grades were given according to the taste of the final formulation. The study concludes the dissolution enhanced as well as taste was masked of Cefpodoxime proxetil using Eudragit EPO and Stearic Acid Polymer in 1:1 ratio.


Author(s): Upadhyay L. K.*, Pande S. V., Chaware V. J. and Biyani K. R

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