The objective of the study was to develop matrix tablets for oral controlled release of Deflazacort. In present study controlled release tablets of deflazocart were successfully developed using wet granulation method. To achieve better patient compliance and for prolonged release of drug from the dosage form. Formulation development of diffusion based controlled release matrix tablets of Deflazacort using polymers such as HPMC K100M, Ethylcellulose 50CPS and HPC and their combinations and selection of the best formulation among them. Flow properties – Angle of repose, loose bulk density, tapped density and also % Carr’s compressibility was determined for all the formulations which showed good flow property. The thickness found uniform, hardness and friability values of all the formulation tablets prepared by wet granulation method were within the limits and found to be mechanically stable. In vitro dissolution results showed that % of drug release was prolonged in formulation F12 that is up to 12 hours when compared to other formulations. This indicates that the drug released from the formulation F12 was effective up to 12 hours.