Abstract

Formulation and evaluation of bifonazole organogel for the application of topical drug delivery system

The main aim of the present study was to prepare and evaluate novel in situ gelling topical drug delivery of bifonazole by using sorbitan monostearate. The formulations were prepared and evaluated for rheological study, appearance, texture, viscosity, measurement of pH, gelling capacity, drug content estimation and in vitro diffusion study. Seven formulations were developed using 70 % oil phase and 30 % aqueous phase. It was found that the pH of all the formulations was in the range of to 5.8 -6.6 that suits for the skin pH, indicating skin compatibility. The IR study was performed to confirm interaction of drugs with formulations, it indicated that there was no drug excipient interactions. The optimized formulation BF4 containing 10% Sorbian monostearate showed prolong release with 83.92% at the end of 8hrs .The developed formulation was stable, non irritant and provided sustained release over 8 hrs.


Author(s): Chinmaya Keshari Sahoo, K. Satyanarayana, Naveen Gandhi Bomma, Koti Reddy Modugu, Prakash Kumar Nayak, Deepak Kumar Sarangi and Tanmaya Keshari Sahoo

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