Formulation and Evaluation of an Antifungal Nail Lacquer for Onychomycosis

In the present work, a medicated antifungal nail lacquer had been developed. The formulation objective was to provide a sustained release of antifungal over extended period of time, so as to reduce frequency of administration, improve clinical efficacy and improve the patient compliance. The nail lacquer formulation was prepared by simple mixing and analyzed for non volatile content, gloss, smoothness to flow, drug diffusion studies, drug content estimation, anti microbial studies. Among all formulation, nail lacquer prepared with 2% drug, 3% nitrocellulose, 0.5% ethyl cellulose, 20% salicylic acid, 5% propylene glycol and 5% urea in H2O2 exhibited good non volatile content, gloss, smoothness to flow, drug release, drug content estimation and antifungal activity. The drug release could be extended up to 48 hr and a complete release of 96.03% was observed. FTIR studies revealed that drug and excipients are compatible. Stability study of selected optimized formulation was done as per ICH guidelines for 1 month, which revealed that no significant change with respect to the evaluations conducted before stability charging. The inhibitory zones for the nail lacquer were evaluated by testing against the Candida albicans on Sabouraud’s Dextrose Agar. The effective zones of inhibitions suggested miconazole nail lacquer exhibiting moderate antifungal activity for the onchomycosis treatment.

Author(s): Vipin K V, Sarath Chandran C, Ann Rose Augusthy, Premaletha K and Maria Rose Kuriakose

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