Fabrication of Glimepiride Hibiscus esculentus Fruit Mucilage and Povidone Sustained Release Matrix Tablets: In vitro evaluation

The main purpose of the present work was to develop matrix tablets of Glimepiride with Hibiscus esculentus fruit mucilage and Povidone and to study its functionality as a matrix forming agent for sustained release tablet formulations. Mucilage from Hibiscus esculentus fruit was extracted, isolated, purified and characterized. Physicochemical properties of the dried powdered mucilage of Hibiscus esculentus fruit were studied. Various formulations of Glimepiride Hibiscus esculentus fruit mucilage and Povidone were prepared. The formulated tablets were tested for mechanical properties, friability, swelling behavior, in vitro drug release pattern and the dissolution data was treated with mathematical modeling and the optimized formulation was tested for accelerated stability studies. The formulated tablets were found to have good mechanical properties, good swelling properties. The in vitro dissolution data was perfectly fitting to zero order and the release of drug from the formulation followed Higuchi’s release. The accelerated stability studies revealed that the tablets retain their characteristics even after stressed storage conditions. From this study it was concluded that the dried Hibiscus esculentus fruit mucilage and Povidone combination can be used as a matrix forming material for making sustained release matrix tablets.

Author(s): Hindustan Abdul Ahad, Sreeramulu J, Sreenivasulu R, Suma Padmaja B and Narasimha Reddy M

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