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Examining the Pattern of Susceptibility and Antibiotic Resistance in Klebsiella pneumoniae Strains Isolated from Urine Samples of Children with Urinary Tract Infections from the Children's Hospital of Tabriz in 2015

Background and Purpose: Klebsiella pneumonia is the most important causes of urinary tract infections in patients. Resistant strains of K. pneumoniae, especially to several antibiotics of different drug classes, have become very prevalent. In most cases, this resistance is such that causes illness exacerbation. The aim of this study is to evaluate the pattern of susceptibility and resistance of K. pneumoniae to some antibiotics isolated from urinary tract infections.

Materials and Method: In this cross-sectional study, we collected 198 strains of K. pneumoniae from patients with urinary tract infections (UTI). Initially, we selected these strains using standard laboratory and microbiology methods as well as culture in specific media. Muller Hinton agar was cultured on the medium by sterile cotton swab in three directions to evaluate the antibiotic susceptibility patterns of the strains, and Kirby-Bauer disk diffusion method was used for antibiogram.

Results: The highest degree of resistance of K. pneumoniae isolates were, respectively, to gentamicin (32.83%) and tetracycline (27.78%) antibiotics, and the highest susceptibility was to amikacin (98.98%) and imipenem (98.96%) antibiotics.

Conclusion: Considering the high prevalence of resistance to antibiotics, early and timely detection of resistant strains seems necessary to select appropriate treatment options and to prevent the spread of resistance.

Author(s): Sevda Leisy-Azar and Amir Reza Ebadi*

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