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Evaluation of Solubl HLA-G and Cytokine Levels in Children with Acute Leukemia Undergoing Allogeneic Stem Cell Transplantation

Statement: There are few studies about cytokines and sHLA-G levels in patients with acute leukemia undergoing allogeneic stem cell transplantation (allo-SCT). We aimed to investigate the role of cytokines and sHLA-G levels measured at five different time points in children with acute leukemia undergoing allo-SCT. Methodology: A total of 41 patients with acute leukemia were recruited in this study. Among them, 26 consecutive patients were examined during the diagnosis of acute leukemia and in the remission period before transplantation (PreTx). The remaining 15 patients were included on the day of transplantation (Tx0). A total of 41 patients with acute leukemia were also examined on the 14th (PostTx14) and 28th (PostTx28) days after transplantation. Serum levels of pro-inflammatory (IL-1, IL-2, IL-6, TNF-α), anti-inflammatory (IL-4, IL-10) cytokines and sHLA-G were measured by ELISA (Bioassay Technology, China). Findings: The median cytokine and sHLA-G levels in leukemia diagnosis and post-transplantation periods (Tx0, PostTx14, PostTx28) were found to be significantly higher than the cytokine and sHLA-G levels in the pretransplantation period (p<0.05). Serum IL-1, IL-4, IL-10, and sHLA-G levels at diagnosis were significantly higher in children with relapse ALL than in children without relapse ALL (p<0.05). Compared with patients

Author(s): Zühre Kaya

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