Evaluation of in-vitro membrane stabilization and thrombolytic activities of MorindaangustifoliaRoxb.

The aim of the present study was to evaluate the in-vitro membrane stabilization and thrombolytic activities of the methanolic extracts of root and leaves of Morinda angustifolia Roxb. Assessment of in-vitro membrane stabilization activity was carried out by hypotonic solution induced hemolysis method in which both root and leaves extracts along with the standard drug acetyl salicylic acid, significantly (p<0.0001) inhibited hemolysis when compared to control. For instance, root and leaves extracts caused maximum inhibition of hemolysis of 40.22% and 21.62% respectively. In in-vitro thrombolytic activity test, 38.26% and 23.66% clots were lysed by root and leaves extract respectively which were also of statistical significance (p<0.0001).

Author(s): Baharul Islam, Afroz Karim, Mohammed Mashrur Chowdhury, ShatabdiBhattacharjee and Syed Mohammed Tareq

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