Evaluation of in vivo wound healing potential of Cassia roxburghii leaves extracts

Cassia roxburghii having the synonym of Cassia marginata, Cathartocarpus marginatus was found in most parts of central and southern India. Cassia species are well known in folk medicine for their laxative and purgative uses. They are also used for treating skin diseases such as ring worm, scabies, eczema and wounds. However there was no scientific evidence justifying the use of Cassia roxburghii in wounds, therefore the present study was aimed at evaluation of wound healing activity of leaves of Cassia roxburghii. In the present study the leaves of Cassia roxburghii were extracted by successive solvent extraction using petroleum ether, Ethyl acetate and Methanol which were studied for wound healing activity by incorporating the extracts in simple ointment base B.P. in concentration of 5% (w/w). Wound healing activity was studied in two types of model in rats viz. excision and incision. In case of the excision wound model wound contraction and period of epithelization was studied while in incision wound model, tensile strength of the wound was measured. Treatment of wound with ointment containing 5% (w/w) methanolic extract showed good wound healing activity.

Author(s): Srinivas K Reddy, Gnananath K, Sanjeeva A Kumar, Vinay D Kumar, Krishna B

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