Evaluation of clobazam loaded ionically cross-linked microspheres using chitosan

Clobazam loaded chitosan microspheres were prepared by the ionic gelation method using sodium tripolyphosphate (Na-TPP) as the crosslinking agent. The use of ionotropic gelation avoids the possibility of the occurrence of the toxic and undersirable effects associated with the use of glutaraldehyde, a chemical crosslinking agent. The prepared microspheres were evaluated for mean particle size and particle size distribution, drug loading, encapsulation efficiency and in-vitro drug release. FT-IR spectroscopic analysis was performed to ascertain drugpolymer interaction, if any during the microsphere preparation. The surface morphology of the prepared microspheres was studied by SEM. With an increase in the crosslinking density the rate of drug release decreased. The results of the DSC and XRD analysis confirmed that clobazam existed as a molecular dispersion in the polymeric microsphere matrix in an amorphous state. From the results of the present investigation it may be concluded that drug loaded chitosan microspheres can be prepared by a simple technique which avoids the use of complex apparatus and special precautions.

Author(s): S. Senthil kumar, Avik Kumar Saha, Kunchu Kavitha and Sanat Kumar Basu

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