In the present study, six medicinally important plants seed (Acacia catechu, Sida cordifolia, Momordica fotida, Albiziz procera, Mesua ferrea and Lantana camare) were screened for their phytochemical and screened for antimicrobial activity by using 4 different solvent, water, Acetone, Petroleum Ether and chloroform. All the plants which are selected for the study contains phytochemicals like alkaloids, flavonoids, tannins, steroids, terpinoids, phenols and saponins. All the extracts showed high to moderate amounts of anti-microbial activity except A. procera against selected gram positive and gram negative bacterial species. The extracts from plants; A.catecu, S, cordifolia, M. foetida and L. camare showed highest zones of inhibition on gram positive bacteria than gram negative species. The bacterial species (B.cereus, Streptococcus pyrogens and S.epidermidis) showed highest sensitivity towards these four extracts. The gram negative bacterium Pseudomonas aeruginosa showed highest sensitivity to these extracts and Shigella flexneri showed highest category of resistance to these extracts. A. catechu, S.cordifolia and L.camare aqueous, acetone and petroleum ether extracts showed the best inhibition zones against these gram negative bacterial species.