Evaluation of Analgesic Activity of Hydroalcoholic Extract of Curcuma longa Rhizomes in Albino Rats

The present study was aimed to investigate analgesic activity of the hydroalcoholic extract of Curcuma longa (HAECL) rhizomes in albino rats. The HAECL (100, 200 and 400 mg/kg; p.o.) was evaluated for its analgesic activity by employing tail immersion test and hot plate test. In tail immersion test the HAECL at a dose of 100, 200 and 400 mg/ kg showed significant (p<0.05), (p<0.01) and (p<0.01) respectively analgesic activity at 30 min time interval but at 60 min time interval all the three doses showed significant (p<0.01) analgesic activity as compared to control group. In hot plate test the test drug at 200 mg/kg and 400 mg/kg body weight showed significant (p<0.01) analgesic activity. The HAECL rhizome shows analgesic activity in albino rats and was comparable with pentazocin. In addition, the acute toxicity study revealed that HAECL have not shown any toxicity on the animals up to the doses of 1000 mg/kg and the phytochemical investigation of the HAECL shows the presence of carbohydrate, terpinoids, tannins, flavonoids, alkaloids and glycosides.

Author(s): Bimlendu Chowdhury, Rajendra Kumar Swain, Sitima Dey and Bhanoji Rao ME

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