Estimation of the Triflusal using derivative Spectrophotometry in bulk drug and formulation

Two simple, rapid, accurate, precise, reliable and economical spectrophotometric methods have been proposed for the determination of Triflusal in bulk and in pharmaceutical formulation. First method is zero order UV Spectrophotometry while second one is first order derivative Spectrophotometry. The developed methods have shown best results in terms of linearity, accuracy, precision, LOD and LOQ for bulk drug and marketed formulations as well. Absorbance was measured at 278 nm for zero order and 240 nm for first order derivative. It obeyed Lambert - Beer’s law in the range of 20-140 μg mL-1 and 10-70 μg mL-1 for zero order and first order respectively. Both methods shows good linearity (r2 = 0.9993 and 0.9998) and was found to be accurate, precise and rugged.

Author(s): Vivekkumar K. Redasani , Amit R. Kothawade, Bhushan J. Mali, Sanjay J. Surana

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