Electrochemical behavior of N-[[(1-methylethyl)amino]carbonyl]-4- [(3- methylphenyl)amino]-3-pyridinesulfonamide on Glassy carbon and Platinum electrodes in Protic media

A voltammetric study of the oxidation and reduction of torasemide has been carried out at the glassy carbon and platinum electrode, respectively. The electrochemical behavior of torasemide was investigated by cyclic, differential pulse stripping and square wave stripping voltammetry using glassy carbon and platinum electrode. Different parameters were tested to optimize the conditions for the determination of torasemide. The dependence of intensities of currents and potentials on concentration, scan rate was investigated. For analytical purposes, a very well resolved diffusion controlled voltammetric peak was obtained in Phosphate and Acetate buffer at pH 4 and 6 for differential pulse and square wave voltammetric techniques, on glassy carbon and platinum electrode, respectively. Based on this study, simple, rapid, selective and sensitive two voltammetric methods were developed for the determination of the torasemide in tablet dosage form.
Author(s): Gunjan Varshney and Digish K Sharma

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