Effects of Zizyphus mauritiana Lam. leaves extract in alloxan induced diabetes and its secondary complications in rats

In the present study we evaluated the effect of 4-week treatment of ethanolic extract of Zizyphus mauritiana Lam. leaves (ZME), on the blood glucose, oral glucose tolerance and biochemical parameters like cholesterol, urea, creatinine and SGPT in alloxan induced diabetic rats. Albino rats (Wistar), weighing between 200-225 g. of either sex were selected for the study. Diabetes was introduced by single tail-vein injection of alloxan (60 mg kg –1). Blood glucose level was detected by glucose oxidase and peroxidase method using commercially available kit. The biochemical parameters (cholesterol, urea, creatinine, bilirubin and SGPT) were analyzed using Transasia Chem-5 Plus v2 auto analyzer using standard kits. Oral glucose tolerance test was performed at the end of 4-weeks. Glucose (2.5 g kg –1) was administered to 12-h fasted rats. Blood sample was collected at various time intervals. The result shows that oral administration of ZME to diabetic animals’ for 4 weeks dose dependently reduced the blood glucose level and it is comparable to that of standard drug metformin. The ZME significantly increases oral glucose tolerance. The extract also reduces elevated cholesterol, urea, creatinine and SGPT level and increases hemoglobin count in diabetic rats. The result of present study proved the hypoglycemic effect of ZME and it was also observed that the extract may delay the onset of some secondary complication reported diabetes.
Author(s): Hemant Une1, M. S. Ghodke, Mohammed Mubashir and J. B. Naik

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